Caulerpin as a potential antiviral drug against herpes simplex virus type 1
Rev. bras. farmacogn
; 22(4): 861-867, jul.-ago. 2012. ilus, tab
Article
in En
| LILACS
| ID: lil-640348
Responsible library:
BR1.1
ABSTRACT
About 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir, foscarnet), their continuous use promotes the selection of resistant strains, mainly in ACV patients. In addition to resistance, the drugs also have toxicity, particularly when administration is prolonged. The study of new molecules isolated from green algae with potential antiviral activity represents a good opportunity for the development of antiviral drugs. Caulerpin, the major product from the marine algae Caulerpa Lamouroux (Caulerpales), is known for its biological activities such as antioxidant, antifungal, acetylcholinesterase inhibitor (AChE) and antibacterial activity. In this work, we show that caulerpin could be an alternative to acyclovir as an anti-HSV-1 drug that inhibits the alpha and beta phases of the replication cycle.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Language:
En
Journal:
Braz. j. pharmacogn.
/
Brazilian journal of pharmacognosy
/
Rev. bras. farmacogn
/
Rev. bras. farmacogn. (Online)
/
Revista brasileira de farmacognosia (Impresso)
Journal subject:
FARMACIA
Year:
2012
Document type:
Article
Affiliation country:
Country of publication: